Comparitive in vitro, in vivo anti-arthritic and anti-inflammatory activities of Plumeria pudica Jacq., Enum. Syst. Pl. 13 1760 and Plumeria rubra L. Sp. Pl. 209 1753 in albino rats

Abstract

The present work aimed to estimate the possible anti-arthritic and anti-inflammatory effects of ethanolic flower extracts of Plumeria pudica and Plumeria rubra. In vitro anti-arthritic activities of flower extracts were investigated through protein denaturation and egg albumin methods. The anti-inflammatory activity of flower extracts (150 and 300 mg/kg) was elucidated by carrageenan-induced paw edema and formaldehyde-induced arthritis, in rats. Results indicated that significant anti-arthritic activity and anti-inflammatory were observed by ethanolic flower extract of P. pudica compared to ethanolic flower extract of P. rubra and the results are comparable with that of standard Diclofenac sodium. The results provided an important basis for developing the flower extracts as a novel anti-inflammatory agent or substitute and for treating arthritis.

Keywords: Anti-inflammatory, anti-arthritic, bovine serum albumin, carrageenan, formaldehyde, Plumeria pudica, Plumeria rubra.

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