Bioprospecting of Coccinia grandis (L.) Voigt leaf: A wild nutraceutical of Bangladesh

Minhajur Rahman, Tasnim Humaira and Urmi Chowdhury

Advancement in Medicinal Plant Research
Published: March 7 2023
Volume 11, Issue 1
Pages 1-8

Abstract

Coccinia grandis (L.) Voigt leaf is a widely consumed leafy vegetable in Bangladesh for a variety of medical purposes. The methanolic leaf extract was investigated for its phytochemical as well as nutraceutical (antioxidant, anti-inflammatory, cytotoxic, and antibacterial) properties to substantiate its traditional uses. It contains bioactive elements such as alkaloids, glycocides, steroids, tannins, phenols, terpenoids, quinines, phlobatanins and protein but lacks flavonoids, saponins, anthraquinone, and coumarin, according to phytochemical analysis. Leaf extract has strong antioxidant (IC₅₀ = 37.334 µg/ml), anti-inflammatory (IC₅₀ = 51.87 µg/ml), and cytotoxic (LC₅₀ = 41.49 µg/ml) activities, according to biological tests. It also had modest antibacterial activity (8 to 12 mm) against Bacillus subtilis, Bacillus cereus, Escherichia coli and Salmonella typhi, with a maximum inhibition zone of 12 mm (250 µg/ml) against Bacillus subtilis.

Keywords: Coccinia grandis, antioxidant activity, anti-inflammatory activity, cytotoxic activity, antibacterial activity.

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